Reproduction Abstracts

Introduction: Cystine-glutamate transporter (xCT) regulates cysteine levels by limiting uptake of cystine and consequently determines glutathione (GSH) contents in the cells. This study was performed to clarify effects of xCT deficiency (KO) on oocyte quality and ovarian function during maternal aging.Materials and methods: Ovaries and plasma were collected from young (2 months) and aged (12 months) C57BL/6 xCT-KO and WT mice at 44 h after PMSG treatment...